KINETIC STUDIES ON METABOLISM OF LIPOPROTEIN LIPASE*
نویسندگان
چکیده
منابع مشابه
Kinetic studies on metabolism of lipoprotein lipase.
Since Hahn demonstrated the clearing of alimentary lipemia by the intravenous injection of heparin, many excellent studies have been done on lipoprotein lipase (LPL). In these studies, however, LPL activities were compared in normal and pathological conditions at a certain time after heparin injection. If the level of LPL activity in the circulating blood changes continuously after heparin inje...
متن کاملComparative studies of vertebrate lipoprotein lipase: a key enzyme of very low density lipoprotein metabolism.
Lipoprotein lipase (LIPL or LPL; E.C.3.1.1.34) serves a dual function as a triglyceride lipase of circulating chylomicrons and very-low-density lipoproteins (VLDL) and facilitates receptor-mediated lipoprotein uptake into heart, muscle and adipose tissue. Comparative LPL amino acid sequences and protein structures and LPL gene locations were examined using data from several vertebrate genome pr...
متن کاملHepatic lipase, lipoprotein metabolism, and atherogenesis.
The role of hepatic lipase as a multifunctional protein that modulates lipoprotein metabolism and atherosclerosis has been extensively documented over the last decade. Hepatic lipase functions as a lipolytic enzyme that hydrolyzes triglycerides and phospholipids present in circulating plasma lipoproteins. Hepatic lipase also serves as a ligand that facilitates lipoprotein uptake by cell surface...
متن کاملLipoprotein lipase: regulation and role in lipoprotein metabolism.
Humans and animals deficient in lipoprotein lipase (EC 3.1.1.34; LPL) develop a massive hypertriacylglycerolaemia (Brunzell, 1995). Hence, LPL-mediated hydrolysis of lipoprotein-triacylglycerols is a necessary step in lipoprotein metabolism. The reaction occurs at ‘binding-lipolysis’ sites at the vascular endothelium (Olivecrona & Olivecrona, 1995). Here the enzyme is anchored by interaction wi...
متن کاملRole of lipoprotein lipase in the regulation of high density lipoprotein apolipoprotein metabolism. Studies in normal and lipoprotein lipase-inhibited monkeys.
Mechanisms that might be responsible for the low levels of high density lipoprotein (HDL) associated with hypertriglyceridemia were studied in an animal model. Specific monoclonal antibodies were infused into female cynomolgus monkeys to inhibit lipoprotein lipase (LPL), the rate-limiting enzyme for triglyceride catabolism. LPL inhibition produced marked and sustained hypertriglyceridemia, with...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1963
ISSN: 0021-9738
DOI: 10.1172/jci104762